Cleavage of the Human Immunoglobulin A1 (IgA1) Hinge Region by IgA1 Proteases Requires Structures in the Fc region of IgA

Secretory immunoglobulin A (IgA) protects the mucosal surfaces against inhaled and ingested pathogens. Many pathogenic bacteria produce IgA1 proteases that cleave in the hinge of IgA1, thus separating the Fab region from the Fc region and making IgA ineffective. Here, we show that Haemophilus influe...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Chintalacharuvu, Koteswara R., Chuang, Philip D., Dragoman, Ashley, Fernandez, Christine Z., Qiu, Jiazhou, Plaut, Andrew G., Trinh, K. Ryan, Gala, Françoise A., Morrison, Sherie L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Molecular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153282/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12704129/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.5.2563-2570.2003
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