Cleavage of the Human Immunoglobulin A1 (IgA1) Hinge Region by IgA1 Proteases Requires Structures in the Fc region of IgA

Secretory immunoglobulin A (IgA) protects the mucosal surfaces against inhaled and ingested pathogens. Many pathogenic bacteria produce IgA1 proteases that cleave in the hinge of IgA1, thus separating the Fab region from the Fc region and making IgA ineffective. Here, we show that Haemophilus influe...

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Bibliografiske detaljer
Main Authors: Chintalacharuvu, Koteswara R., Chuang, Philip D., Dragoman, Ashley, Fernandez, Christine Z., Qiu, Jiazhou, Plaut, Andrew G., Trinh, K. Ryan, Gala, Françoise A., Morrison, Sherie L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC153282/
https://ncbi.nlm.nih.gov/pubmed/12704129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.5.2563-2570.2003
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