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Effect of Mutations in the Human Immunoglobulin A1 (IgA1) Hinge on Its Susceptibility to Cleavage by Diverse Bacterial IgA1 Proteases

Components of the human immunoglobulin A1 (IgA1) hinge governing sensitivity to cleavage by bacterial IgA1 proteases were investigated. Recombinant antibodies with distinct hinge mutations were constructed from a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region. This hybrid...

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Bibliographische Detailangaben
Hauptverfasser: Senior, Bernard W., Woof, Jenny M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064975/
https://ncbi.nlm.nih.gov/pubmed/15731049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.3.1515-1522.2005
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