Amino Acid Sequence Requirements in the Hinge of Human Immunoglobulin A1 (IgA1) for Cleavage by Streptococcal IgA1 Proteases

The amino acid sequence requirements in the hinge of human immunoglobulin A1 (IgA1) for cleavage by IgA1 proteases of different species of Streptococcus were investigated. Recombinant IgA1 antibodies were generated with point mutations at proline 227 and threonine 228, the residues lying on either s...

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Detalhes bibliográficos
Main Authors: Batten, Margaret R., Senior, Bernard W., Kilian, Mogens, Woof, Jenny M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC148859/
https://ncbi.nlm.nih.gov/pubmed/12595464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.3.1462-1469.2003
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