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Cleavage of the Human Immunoglobulin A1 (IgA1) Hinge Region by IgA1 Proteases Requires Structures in the Fc region of IgA

Secretory immunoglobulin A (IgA) protects the mucosal surfaces against inhaled and ingested pathogens. Many pathogenic bacteria produce IgA1 proteases that cleave in the hinge of IgA1, thus separating the Fab region from the Fc region and making IgA ineffective. Here, we show that Haemophilus influe...

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Wedi'i Gadw mewn:
Cyhoeddwyd yn:Infect Immun
Prif Awduron: Chintalacharuvu, Koteswara R., Chuang, Philip D., Dragoman, Ashley, Fernandez, Christine Z., Qiu, Jiazhou, Plaut, Andrew G., Trinh, K. Ryan, Gala, Françoise A., Morrison, Sherie L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2003
Pynciau:
Molecular Pathogenesis
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153282/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12704129/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.5.2563-2570.2003
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