Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in Helicobacter pylori and in Escherichia coli Containing a Cloned H. pylori rdxA(+) (Nitroreductase) Gene

Much of the normal high sensitivity of wild-type Helicobacter pylori to metronidazole (Mtz) depends on rdxA (HP0954), a gene encoding a novel nitroreductase that catalyzes the conversion of Mtz from a harmless prodrug to a bactericidal agent. Here we report that levels of Mtz that partially inhibit...

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Detalles Bibliográficos

Publicado en:	J Bacteriol
Principais autores:	Sisson, Gary, Jeong, Jin-Yong, Goodwin, Avery, Bryden, Louis, Rossler, Norma, Lim-Morrison, Sabrina, Raudonikiene, Ausra, Berg, Douglas E., Hoffman, Paul S.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2000
Assuntos:	Population Genetics and Evolution
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC94656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10960092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.18.5091-5096.2000
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