Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in Helicobacter pylori and in Escherichia coli Containing a Cloned H. pylori rdxA(+) (Nitroreductase) Gene

Much of the normal high sensitivity of wild-type Helicobacter pylori to metronidazole (Mtz) depends on rdxA (HP0954), a gene encoding a novel nitroreductase that catalyzes the conversion of Mtz from a harmless prodrug to a bactericidal agent. Here we report that levels of Mtz that partially inhibit...

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Autors principals: Sisson, Gary, Jeong, Jin-Yong, Goodwin, Avery, Bryden, Louis, Rossler, Norma, Lim-Morrison, Sabrina, Raudonikiene, Ausra, Berg, Douglas E., Hoffman, Paul S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Population Genetics and Evolution
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC94656/
https://ncbi.nlm.nih.gov/pubmed/10960092
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