Sequential Inactivation of rdxA (HP0954) and frxA (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in Helicobacter pylori

Helicobacter pylori is a human-pathogenic bacterial species that is subdivided geographically, with different genotypes predominating in different parts of the world. Here we test and extend an earlier conclusion that metronidazole (Mtz) resistance is due to mutation in rdxA (HP0954), which encodes...

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Main Authors: Jeong, Jin-Yong, Mukhopadhyay, Asish K., Dailidiene, Daiva, Wang, Yipeng, Velapatiño, Billie, Gilman, Robert H., Parkinson, Alan J., Nair, G. Balakrish, Wong, Benjamin C. Y., Lam, Shiu Kum, Mistry, Rajesh, Segal, Isidore, Yuan, Yuan, Gao, Hua, Alarcon, Teresa, Brea, MaNuel Lopez, Ito, Yoshiyuki, Kersulyte, Dangeruta, Lee, Hae-Kyung, Gong, Yan, Goodwin, Avery, Hoffman, Paul S., Berg, Douglas E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Population Genetics and Evolution
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC94655/
https://ncbi.nlm.nih.gov/pubmed/10960091
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