Sequential Inactivation of rdxA (HP0954) and frxA (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in Helicobacter pylori

Helicobacter pylori is a human-pathogenic bacterial species that is subdivided geographically, with different genotypes predominating in different parts of the world. Here we test and extend an earlier conclusion that metronidazole (Mtz) resistance is due to mutation in rdxA (HP0954), which encodes...

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Main Authors: Jeong, Jin-Yong, Mukhopadhyay, Asish K., Dailidiene, Daiva, Wang, Yipeng, Velapatiño, Billie, Gilman, Robert H., Parkinson, Alan J., Nair, G. Balakrish, Wong, Benjamin C. Y., Lam, Shiu Kum, Mistry, Rajesh, Segal, Isidore, Yuan, Yuan, Gao, Hua, Alarcon, Teresa, Brea, MaNuel Lopez, Ito, Yoshiyuki, Kersulyte, Dangeruta, Lee, Hae-Kyung, Gong, Yan, Goodwin, Avery, Hoffman, Paul S., Berg, Douglas E.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2000
主題:
Population Genetics and Evolution
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC94655/
https://ncbi.nlm.nih.gov/pubmed/10960091
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