Sequential Inactivation of rdxA (HP0954) and frxA (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in Helicobacter pylori

Helicobacter pylori is a human-pathogenic bacterial species that is subdivided geographically, with different genotypes predominating in different parts of the world. Here we test and extend an earlier conclusion that metronidazole (Mtz) resistance is due to mutation in rdxA (HP0954), which encodes...

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Pubblicato in:	J Bacteriol
Autori principali:	Jeong, Jin-Yong, Mukhopadhyay, Asish K., Dailidiene, Daiva, Wang, Yipeng, Velapatiño, Billie, Gilman, Robert H., Parkinson, Alan J., Nair, G. Balakrish, Wong, Benjamin C. Y., Lam, Shiu Kum, Mistry, Rajesh, Segal, Isidore, Yuan, Yuan, Gao, Hua, Alarcon, Teresa, Brea, MaNuel Lopez, Ito, Yoshiyuki, Kersulyte, Dangeruta, Lee, Hae-Kyung, Gong, Yan, Goodwin, Avery, Hoffman, Paul S., Berg, Douglas E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Population Genetics and Evolution
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC94655/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10960091/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.18.5082-5090.2000
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