Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in Helicobacter pylori and in Escherichia coli Containing a Cloned H. pylori rdxA(+) (Nitroreductase) Gene

Much of the normal high sensitivity of wild-type Helicobacter pylori to metronidazole (Mtz) depends on rdxA (HP0954), a gene encoding a novel nitroreductase that catalyzes the conversion of Mtz from a harmless prodrug to a bactericidal agent. Here we report that levels of Mtz that partially inhibit...

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Manylion Llyfryddiaeth

Cyhoeddwyd yn:	J Bacteriol
Prif Awduron:	Sisson, Gary, Jeong, Jin-Yong, Goodwin, Avery, Bryden, Louis, Rossler, Norma, Lim-Morrison, Sabrina, Raudonikiene, Ausra, Berg, Douglas E., Hoffman, Paul S.
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	American Society for Microbiology (ASM) 2000
Pynciau:	Population Genetics and Evolution
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC94656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10960092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.18.5091-5096.2000
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