Insertion of Mini-IS605 and Deletion of Adjacent Sequences in the Nitroreductase (rdxA) Gene Cause Metronidazole Resistance in Helicobacter pylori NCTC11637

We found that NCTC11637, the type strain of Helicobacter pylori, the causative agent of peptic ulcer disease and an early risk factor for gastric cancer, is metronidazole resistant. DNA transformation, PCR-based restriction analysis, and DNA sequencing collectively showed that the metronidazole resi...

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Main Authors: Debets-Ossenkopp, Yvette J., Pot, Raymond G. J., van Westerloo, David J., Goodwin, Avery, Vandenbroucke-Grauls, Christina M. J. E., Berg, Douglas E., Hoffman, Paul S., Kusters, Johannes G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89539/
https://ncbi.nlm.nih.gov/pubmed/10543743
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