Insertion of Mini-IS605 and Deletion of Adjacent Sequences in the Nitroreductase (rdxA) Gene Cause Metronidazole Resistance in Helicobacter pylori NCTC11637

We found that NCTC11637, the type strain of Helicobacter pylori, the causative agent of peptic ulcer disease and an early risk factor for gastric cancer, is metronidazole resistant. DNA transformation, PCR-based restriction analysis, and DNA sequencing collectively showed that the metronidazole resi...

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Autori principali: Debets-Ossenkopp, Yvette J., Pot, Raymond G. J., van Westerloo, David J., Goodwin, Avery, Vandenbroucke-Grauls, Christina M. J. E., Berg, Douglas E., Hoffman, Paul S., Kusters, Johannes G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1999
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC89539/
https://ncbi.nlm.nih.gov/pubmed/10543743
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