Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

Peptide deformylase (PDF) is an essential bacterial metalloenzyme which deformylates the N-formylmethionine of newly synthesized polypeptides and as such represents a novel target for antibacterial chemotherapy. To identify novel PDF inhibitors, we screened a metalloenzyme inhibitor library and iden...

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Bibliografiske detaljer
Main Authors: Clements, John M., Beckett, R. Paul, Brown, Anthony, Catlin, Graham, Lobell, Mario, Palan, Shilpa, Thomas, Wayne, Whittaker, Mark, Wood, Stephen, Salama, Sameeh, Baker, Patrick J., Rodgers, H. Fiona, Barynin, Vladimir, Rice, David W., Hunter, Michael G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC90327/
https://ncbi.nlm.nih.gov/pubmed/11158755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.2.563-570.2001
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