Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

Peptide deformylase (PDF) is an essential bacterial metalloenzyme which deformylates the N-formylmethionine of newly synthesized polypeptides and as such represents a novel target for antibacterial chemotherapy. To identify novel PDF inhibitors, we screened a metalloenzyme inhibitor library and iden...

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Main Authors: Clements, John M., Beckett, R. Paul, Brown, Anthony, Catlin, Graham, Lobell, Mario, Palan, Shilpa, Thomas, Wayne, Whittaker, Mark, Wood, Stephen, Salama, Sameeh, Baker, Patrick J., Rodgers, H. Fiona, Barynin, Vladimir, Rice, David W., Hunter, Michael G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC90327/
https://ncbi.nlm.nih.gov/pubmed/11158755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.2.563-570.2001
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