Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

Peptide deformylase (PDF) is an essential bacterial metalloenzyme which deformylates the N-formylmethionine of newly synthesized polypeptides and as such represents a novel target for antibacterial chemotherapy. To identify novel PDF inhibitors, we screened a metalloenzyme inhibitor library and iden...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Clements, John M., Beckett, R. Paul, Brown, Anthony, Catlin, Graham, Lobell, Mario, Palan, Shilpa, Thomas, Wayne, Whittaker, Mark, Wood, Stephen, Salama, Sameeh, Baker, Patrick J., Rodgers, H. Fiona, Barynin, Vladimir, Rice, David W., Hunter, Michael G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90327/
https://ncbi.nlm.nih.gov/pubmed/11158755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.2.563-570.2001
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi