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Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

Peptide deformylase (PDF) is an essential bacterial metalloenzyme which deformylates the N-formylmethionine of newly synthesized polypeptides and as such represents a novel target for antibacterial chemotherapy. To identify novel PDF inhibitors, we screened a metalloenzyme inhibitor library and iden...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Clements, John M., Beckett, R. Paul, Brown, Anthony, Catlin, Graham, Lobell, Mario, Palan, Shilpa, Thomas, Wayne, Whittaker, Mark, Wood, Stephen, Salama, Sameeh, Baker, Patrick J., Rodgers, H. Fiona, Barynin, Vladimir, Rice, David W., Hunter, Michael G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2001
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90327/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158755/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.2.563-570.2001
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