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Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

Peptide deformylase (PDF) is an essential bacterial metalloenzyme which deformylates the N-formylmethionine of newly synthesized polypeptides and as such represents a novel target for antibacterial chemotherapy. To identify novel PDF inhibitors, we screened a metalloenzyme inhibitor library and iden...

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Sparad:
I publikationen:Antimicrob Agents Chemother
Huvudupphov: Clements, John M., Beckett, R. Paul, Brown, Anthony, Catlin, Graham, Lobell, Mario, Palan, Shilpa, Thomas, Wayne, Whittaker, Mark, Wood, Stephen, Salama, Sameeh, Baker, Patrick J., Rodgers, H. Fiona, Barynin, Vladimir, Rice, David W., Hunter, Michael G.
Materialtyp: Artigo
Språk:Inglês
Utgiven: American Society for Microbiology (ASM) 2001
Ämnen:
Experimental Therapeutics
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90327/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158755/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.2.563-570.2001
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