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Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

Peptide deformylase (PDF) is an essential bacterial metalloenzyme which deformylates the N-formylmethionine of newly synthesized polypeptides and as such represents a novel target for antibacterial chemotherapy. To identify novel PDF inhibitors, we screened a metalloenzyme inhibitor library and iden...

Szczegółowa specyfikacja

Zapisane w:
Wydane w:Antimicrob Agents Chemother
Główni autorzy: Clements, John M., Beckett, R. Paul, Brown, Anthony, Catlin, Graham, Lobell, Mario, Palan, Shilpa, Thomas, Wayne, Whittaker, Mark, Wood, Stephen, Salama, Sameeh, Baker, Patrick J., Rodgers, H. Fiona, Barynin, Vladimir, Rice, David W., Hunter, Michael G.
Format: Artigo
Język:Inglês
Wydane: American Society for Microbiology (ASM) 2001
Hasła przedmiotowe:
Experimental Therapeutics
Dostęp online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90327/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158755/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.2.563-570.2001
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