Interstrain Variation in the Human Cytomegalovirus DNA Polymerase Sequence and Its Effect on Genotypic Diagnosis of Antiviral Drug Resistance

The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons. Almost all variation occurred outside of c...

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Библиографические подробности
Главные авторы: Chou, Sunwen, Lurain, Nell S., Weinberg, Adriana, Cai, Guang-Yung, Sharma, Prem L., Crumpacker, Clyde S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 1999
Предметы:
Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC89307/
https://ncbi.nlm.nih.gov/pubmed/10348781
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