Interstrain Variation in the Human Cytomegalovirus DNA Polymerase Sequence and Its Effect on Genotypic Diagnosis of Antiviral Drug Resistance

The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons. Almost all variation occurred outside of cons...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Chou, Sunwen, Lurain, Nell S., Weinberg, Adriana, Cai, Guang-Yung, Sharma, Prem L., Crumpacker, Clyde S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89307/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10348781/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.6.1500
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