Interstrain Variation in the Human Cytomegalovirus DNA Polymerase Sequence and Its Effect on Genotypic Diagnosis of Antiviral Drug Resistance

The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons. Almost all variation occurred outside of cons...

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Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Chou, Sunwen, Lurain, Nell S., Weinberg, Adriana, Cai, Guang-Yung, Sharma, Prem L., Crumpacker, Clyde S.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1999
Subjects:	Antiviral Agents
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89307/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10348781/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.6.1500
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