Interstrain Variation in the Human Cytomegalovirus DNA Polymerase Sequence and Its Effect on Genotypic Diagnosis of Antiviral Drug Resistance

The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons. Almost all variation occurred outside of cons...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Chou, Sunwen, Lurain, Nell S., Weinberg, Adriana, Cai, Guang-Yung, Sharma, Prem L., Crumpacker, Clyde S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89307/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10348781/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.6.1500
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!