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Interstrain Variation in the Human Cytomegalovirus DNA Polymerase Sequence and Its Effect on Genotypic Diagnosis of Antiviral Drug Resistance

The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons. Almost all variation occurred outside of c...

詳細記述

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書誌詳細
主要な著者: Chou, Sunwen, Lurain, Nell S., Weinberg, Adriana, Cai, Guang-Yung, Sharma, Prem L., Crumpacker, Clyde S.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 1999
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC89307/
https://ncbi.nlm.nih.gov/pubmed/10348781
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