Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases

Chimeric nucleases that are hybrids between a nonspecific DNA cleavage domain and a zinc finger DNA recognition domain were tested for their ability to find and cleave their target sites in living cells. Both engineered DNA substrates and the nucleases were injected into Xenopus laevis oocyte nuclei...

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Detalhes bibliográficos
Main Authors: Bibikova, Marina, Carroll, Dana, Segal, David J., Trautman, Jonathan K., Smith, Jeff, Kim, Yang-Gyun, Chandrasegaran, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC88802/
https://ncbi.nlm.nih.gov/pubmed/11113203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.1.289-297.2001
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