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Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases
Chimeric nucleases that are hybrids between a nonspecific DNA cleavage domain and a zinc finger DNA recognition domain were tested for their ability to find and cleave their target sites in living cells. Both engineered DNA substrates and the nucleases were injected into Xenopus laevis oocyte nuclei...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2001
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC88802/ https://ncbi.nlm.nih.gov/pubmed/11113203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.1.289-297.2001 |
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