Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases

Chimeric nucleases that are hybrids between a nonspecific DNA cleavage domain and a zinc finger DNA recognition domain were tested for their ability to find and cleave their target sites in living cells. Both engineered DNA substrates and the nucleases were injected into Xenopus laevis oocyte nuclei...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bibikova, Marina, Carroll, Dana, Segal, David J., Trautman, Jonathan K., Smith, Jeff, Kim, Yang-Gyun, Chandrasegaran, Srinivasan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
DNA Dynamics and Chromosome Structure
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC88802/
https://ncbi.nlm.nih.gov/pubmed/11113203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.1.289-297.2001
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