Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases

Chimeric nucleases that are hybrids between a nonspecific DNA cleavage domain and a zinc finger DNA recognition domain were tested for their ability to find and cleave their target sites in living cells. Both engineered DNA substrates and the nucleases were injected into Xenopus laevis oocyte nuclei...

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Dettagli Bibliografici
Autori principali: Bibikova, Marina, Carroll, Dana, Segal, David J., Trautman, Jonathan K., Smith, Jeff, Kim, Yang-Gyun, Chandrasegaran, Srinivasan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
DNA Dynamics and Chromosome Structure
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC88802/
https://ncbi.nlm.nih.gov/pubmed/11113203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.1.289-297.2001
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