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Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases

Chimeric nucleases that are hybrids between a nonspecific DNA cleavage domain and a zinc finger DNA recognition domain were tested for their ability to find and cleave their target sites in living cells. Both engineered DNA substrates and the nucleases were injected into Xenopus laevis oocyte nuclei...

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Udgivet i:Mol Cell Biol
Principais autores: Bibikova, Marina, Carroll, Dana, Segal, David J., Trautman, Jonathan K., Smith, Jeff, Kim, Yang-Gyun, Chandrasegaran, Srinivasan
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2001
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC88802/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11113203/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.1.289-297.2001
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