The Elongation Domain of ELL Is Dispensable but Its ELL-Associated Factor 1 Interaction Domain Is Essential for MLL-ELL-Induced Leukemogenesis

The MLL-ELL chimeric gene is the product of the (11;19)(q23p13.1) translocation associated with de novo and therapy-related acute myeloid leukemias (AML). ELL is an RNA polymerase II elongation factor that interacts with the recently identified EAF1 (ELL associated factor 1) protein. EAF1 contains a...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Luo, Roger T., Lavau, Catherine, Du, Changchun, Simone, Federico, Polak, Paul E., Kawamata, Shin, Thirman, Michael J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2001
विषय:
Cell Growth and Development
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC87288/
https://ncbi.nlm.nih.gov/pubmed/11463848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5678-5687.2001
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