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Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia

As a result of the recurring translocation t(11;16) (q23;p13.3), MLL (mixed-lineage leukemia) is fused in frame to CBP (CREB binding protein). This translocation has been documented almost exclusively in cases of acute leukemia or myelodysplasia secondary to therapy with drugs that target DNA topo i...

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Bibliografiska uppgifter
Huvudupphovsmän: Lavau, Catherine, Du, Changchun, Thirman, Michael, Zeleznik-Le, Nancy
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2000
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC302066/
https://ncbi.nlm.nih.gov/pubmed/10970858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.17.4655
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