The Elongation Domain of ELL Is Dispensable but Its ELL-Associated Factor 1 Interaction Domain Is Essential for MLL-ELL-Induced Leukemogenesis

The MLL-ELL chimeric gene is the product of the (11;19)(q23p13.1) translocation associated with de novo and therapy-related acute myeloid leukemias (AML). ELL is an RNA polymerase II elongation factor that interacts with the recently identified EAF1 (ELL associated factor 1) protein. EAF1 contains a...

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Autors principals: Luo, Roger T., Lavau, Catherine, Du, Changchun, Simone, Federico, Polak, Paul E., Kawamata, Shin, Thirman, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC87288/
https://ncbi.nlm.nih.gov/pubmed/11463848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5678-5687.2001
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