Akt-Dependent Phosphorylation of p21(Cip1) Regulates PCNA Binding and Proliferation of Endothelial Cells

The protein kinase Akt is activated by growth factors and promotes cell survival and cell cycle progression. Here, we demonstrate that Akt phosphorylates the cell cycle inhibitory protein p21(Cip1) at Thr 145 in vitro and in intact cells as shown by in vitro kinase assays, site-directed mutagenesis,...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Rössig, Lothar, Jadidi, Amir S., Urbich, Carmen, Badorff, Cornel, Zeiher, Andreas M., Dimmeler, Stefanie
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11463845/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.16.5644-5657.2001
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