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Akt-Dependent Phosphorylation of p21(Cip1) Regulates PCNA Binding and Proliferation of Endothelial Cells
The protein kinase Akt is activated by growth factors and promotes cell survival and cell cycle progression. Here, we demonstrate that Akt phosphorylates the cell cycle inhibitory protein p21(Cip1) at Thr 145 in vitro and in intact cells as shown by in vitro kinase assays, site-directed mutagenesis,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC87285/ https://ncbi.nlm.nih.gov/pubmed/11463845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5644-5657.2001 |
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