Akt-Dependent Phosphorylation of p21(Cip1) Regulates PCNA Binding and Proliferation of Endothelial Cells

The protein kinase Akt is activated by growth factors and promotes cell survival and cell cycle progression. Here, we demonstrate that Akt phosphorylates the cell cycle inhibitory protein p21(Cip1) at Thr 145 in vitro and in intact cells as shown by in vitro kinase assays, site-directed mutagenesis,...

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Autors principals: Rössig, Lothar, Jadidi, Amir S., Urbich, Carmen, Badorff, Cornel, Zeiher, Andreas M., Dimmeler, Stefanie
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC87285/
https://ncbi.nlm.nih.gov/pubmed/11463845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5644-5657.2001
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