Akt-Dependent Phosphorylation of p21(Cip1) Regulates PCNA Binding and Proliferation of Endothelial Cells

The protein kinase Akt is activated by growth factors and promotes cell survival and cell cycle progression. Here, we demonstrate that Akt phosphorylates the cell cycle inhibitory protein p21(Cip1) at Thr 145 in vitro and in intact cells as shown by in vitro kinase assays, site-directed mutagenesis,...

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Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Rössig, Lothar, Jadidi, Amir S., Urbich, Carmen, Badorff, Cornel, Zeiher, Andreas M., Dimmeler, Stefanie
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2001
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11463845/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.16.5644-5657.2001
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