Akt-Dependent Phosphorylation of p21(Cip1) Regulates PCNA Binding and Proliferation of Endothelial Cells

The protein kinase Akt is activated by growth factors and promotes cell survival and cell cycle progression. Here, we demonstrate that Akt phosphorylates the cell cycle inhibitory protein p21(Cip1) at Thr 145 in vitro and in intact cells as shown by in vitro kinase assays, site-directed mutagenesis,...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Mol Cell Biol
Päätekijät:	Rössig, Lothar, Jadidi, Amir S., Urbich, Carmen, Badorff, Cornel, Zeiher, Andreas M., Dimmeler, Stefanie
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Taylor & Francis 2001
Aiheet:	Cell Growth and Development
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11463845/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.16.5644-5657.2001
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