Akt-Dependent Phosphorylation of p21(Cip1) Regulates PCNA Binding and Proliferation of Endothelial Cells

The protein kinase Akt is activated by growth factors and promotes cell survival and cell cycle progression. Here, we demonstrate that Akt phosphorylates the cell cycle inhibitory protein p21(Cip1) at Thr 145 in vitro and in intact cells as shown by in vitro kinase assays, site-directed mutagenesis,...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Rössig, Lothar, Jadidi, Amir S., Urbich, Carmen, Badorff, Cornel, Zeiher, Andreas M., Dimmeler, Stefanie
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 2001
Témata:	Cell Growth and Development
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11463845/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.16.5644-5657.2001
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