Akt-Dependent Phosphorylation of p21(Cip1) Regulates PCNA Binding and Proliferation of Endothelial Cells

The protein kinase Akt is activated by growth factors and promotes cell survival and cell cycle progression. Here, we demonstrate that Akt phosphorylates the cell cycle inhibitory protein p21(Cip1) at Thr 145 in vitro and in intact cells as shown by in vitro kinase assays, site-directed mutagenesis,...

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出版年:	Mol Cell Biol
主要な著者:	Rössig, Lothar, Jadidi, Amir S., Urbich, Carmen, Badorff, Cornel, Zeiher, Andreas M., Dimmeler, Stefanie
フォーマット:	Artigo
言語:	Inglês
出版事項:	Taylor & Francis 2001
主題:	Cell Growth and Development
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11463845/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.16.5644-5657.2001
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