Hepatic Nuclear Factor 1-α Directs Nucleosomal Hyperacetylation to Its Tissue-Specific Transcriptional Targets

Mutations in the gene encoding hepatic nuclear factor 1-α (HNF1-α) cause a subtype of human diabetes resulting from selective pancreatic β-cell dysfunction. We have analyzed mice lacking HNF1-α to study how this protein controls β-cell-specific transcription in vivo. We show that HNF1-α is essential...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Párrizas, Marcelina, Maestro, Miguel A., Boj, Sylvia F., Paniagua, Amaya, Casamitjana, Roser, Gomis, Ramon, Rivera, Francisca, Ferrer, Jorge
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2001
Soggetti:	Transcriptional Regulation
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86965/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11287626/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.9.3234-3243.2001
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