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Hepatic Nuclear Factor 1-α Directs Nucleosomal Hyperacetylation to Its Tissue-Specific Transcriptional Targets

Mutations in the gene encoding hepatic nuclear factor 1-α (HNF1-α) cause a subtype of human diabetes resulting from selective pancreatic β-cell dysfunction. We have analyzed mice lacking HNF1-α to study how this protein controls β-cell-specific transcription in vivo. We show that HNF1-α is essential...

Deskribapen osoa

Gorde:
Argitaratua izan da:Mol Cell Biol
Egile Nagusiak: Párrizas, Marcelina, Maestro, Miguel A., Boj, Sylvia F., Paniagua, Amaya, Casamitjana, Roser, Gomis, Ramon, Rivera, Francisca, Ferrer, Jorge
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2001
Gaiak:
Transcriptional Regulation
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86965/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11287626/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.9.3234-3243.2001
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