The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia
Summary: Thrombocytopenia-absent radius (TAR) syndrome is caused by RBM8A insufficiency. We generated megakaryocyte-specific Rbm8a knockout (Rbm8aKOMK) mice that exhibited marked thrombocytopenia, internal hemorrhage, and splenomegaly, providing evidence that genetic deficiency of Rbm8a causes a dis...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2021-11-01
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| Serie: | iScience |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S2589004221013390 |
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