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Hepatic Nuclear Factor 1-α Directs Nucleosomal Hyperacetylation to Its Tissue-Specific Transcriptional Targets

Mutations in the gene encoding hepatic nuclear factor 1-α (HNF1-α) cause a subtype of human diabetes resulting from selective pancreatic β-cell dysfunction. We have analyzed mice lacking HNF1-α to study how this protein controls β-cell-specific transcription in vivo. We show that HNF1-α is essential...

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Udgivet i:Mol Cell Biol
Principais autores: Párrizas, Marcelina, Maestro, Miguel A., Boj, Sylvia F., Paniagua, Amaya, Casamitjana, Roser, Gomis, Ramon, Rivera, Francisca, Ferrer, Jorge
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2001
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86965/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11287626/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.9.3234-3243.2001
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