Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

Mutations in the genes encoding hepatocyte nuclear factor 4α (HNF-4α) and HNF-1α impair insulin secretion and cause maturity onset diabetes of the young (MODY). HNF-4α is known to be an essential positive regulator of HNF-1α. More recent data demonstrates that HNF-4α expression is dependent on HNF-1...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Hansen, Sara K., Párrizas, Marcelina, Jensen, Maria L., Pruhova, Stepanka, Ek, Jakob, Boj, Sylvia F., Johansen, Anders, Maestro, Miguel A., Rivera, Francisca, Eiberg, Hans, Andel, Michal, Lebl, Jan, Pedersen, Oluf, Ferrer, Jorge, Hansen, Torben
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2002
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC151122/
https://ncbi.nlm.nih.gov/pubmed/12235114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15085
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi