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A transcription factor regulatory circuit in differentiated pancreatic cells
Mutations in the human genes encoding hepatocyte nuclear factors (HNF) 1α, 1β, 4α, and IPF1(PDX1/IDX1/STF1) result in pancreatic β cell dysfunction and diabetes mellitus. In hepatocytes, hnf4α controls the transcription of hnf1α, suggesting that this same interaction may operate in β cells and thus...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC64707/ https://ncbi.nlm.nih.gov/pubmed/11717395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241349398 |
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