A transcription factor regulatory circuit in differentiated pancreatic cells

Mutations in the human genes encoding hepatocyte nuclear factors (HNF) 1α, 1β, 4α, and IPF1(PDX1/IDX1/STF1) result in pancreatic β cell dysfunction and diabetes mellitus. In hepatocytes, hnf4α controls the transcription of hnf1α, suggesting that this same interaction may operate in β cells and thus...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Boj, Sylvia F., Párrizas, Marcelina, Maestro, Miguel A., Ferrer, Jorge
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64707/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11717395/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241349398
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