A transcription factor regulatory circuit in differentiated pancreatic cells
Mutations in the human genes encoding hepatocyte nuclear factors (HNF) 1α, 1β, 4α, and IPF1(PDX1/IDX1/STF1) result in pancreatic β cell dysfunction and diabetes mellitus. In hepatocytes, hnf4α controls the transcription of hnf1α, suggesting that this same interaction may operate in β cells and thus...
Furkejuvvon:
| Publikašuvnnas: | Proc Natl Acad Sci U S A |
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| Váldodahkkit: | , , , |
| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
National Academy of Sciences
2001
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| Fáttát: | |
| Liŋkkat: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64707/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11717395/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241349398 |
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