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Retinoblastoma Protein Transcriptional Repression through Histone Deacetylation of a Single Nucleosome
The retinoblastoma protein, pRb, controls transcription through recruitment of histone deacetylase to particular E2F-responsive genes. We determined the acetylation level of individual nucleosomes present in the cyclin E promoter of RB(+/+) and RB(−/−) mouse embryo fibroblasts. We also determined th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133558/ https://ncbi.nlm.nih.gov/pubmed/11784861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.3.856-865.2002 |
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