Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

Mutations in the genes encoding hepatocyte nuclear factor 4α (HNF-4α) and HNF-1α impair insulin secretion and cause maturity onset diabetes of the young (MODY). HNF-4α is known to be an essential positive regulator of HNF-1α. More recent data demonstrates that HNF-4α expression is dependent on HNF-1...

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Main Authors: Hansen, Sara K., Párrizas, Marcelina, Jensen, Maria L., Pruhova, Stepanka, Ek, Jakob, Boj, Sylvia F., Johansen, Anders, Maestro, Miguel A., Rivera, Francisca, Eiberg, Hans, Andel, Michal, Lebl, Jan, Pedersen, Oluf, Ferrer, Jorge, Hansen, Torben
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2002
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC151122/
https://ncbi.nlm.nih.gov/pubmed/12235114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15085
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