Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom

Dry leaves of kratom (mitragyna speciosa) are anecdotally consumed as pain relievers and antidotes against opioid withdrawal and alcohol use disorders. There are at least 54 alkaloids in kratom; however, investigations to date have focused around mitragynine, 7-hydroxy mitragynine (7OH), and mitragy...

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Pubblicato in:ACS Chem Neurosci
Autori principali: Chakraborty, Soumen, Uprety, Rajendra, Daibani, Amal E., Rouzic, Valerie L., Hunkele, Amanda, Appourchaux, Kevin, Eans, Shainnel O., Nuthikattu, Nitin, Jilakara, Rahul, Thammavong, Lisa, Pasternak, Gavril W., Pan, Ying-Xian, McLaughlin, Jay P., Che, Tao, Majumdar, Susruta
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8328003/
https://ncbi.nlm.nih.gov/pubmed/34213886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.1c00149
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