Temperature effects on RNA polymerase initiation kinetics reveal which open complex initiates and that bubble collapse is stepwise

Transcription initiation is highly regulated by promoter sequence, transcription factors, and ligands. All known transcription inhibitors, an important class of antibiotics, act in initiation. To understand regulation and inhibition, the biophysical mechanisms of formation and stabilization of the “...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Plaskon, Dylan M., Henderson, Kate L., Felth, Lindsey C., Molzahn, Cristen M., Evensen, Claire, Dyke, Sarah, Shkel, Irina A., Record, M. Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325161/
https://ncbi.nlm.nih.gov/pubmed/34290140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021941118
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