Mechanism of transcription initiation and promoter escape by E. coli RNA polymerase

To investigate roles of the discriminator and open complex (OC) lifetime in transcription initiation by Escherichia coli RNA polymerase (RNAP; α(2)ββ’ωσ(70)), we compare productive and abortive initiation rates, short RNA distributions, and OC lifetime for the λP(R) and T7A1 promoters and variants w...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Henderson, Kate L., Felth, Lindsey C., Molzahn, Cristen M., Shkel, Irina, Wang, Si, Chhabra, Munish, Ruff, Emily F., Bieter, Lauren, Kraft, Joseph E., Record, M. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393250/
https://ncbi.nlm.nih.gov/pubmed/28348246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618675114
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