Mechanism of transcription initiation and promoter escape by E. coli RNA polymerase

To investigate roles of the discriminator and open complex (OC) lifetime in transcription initiation by Escherichia coli RNA polymerase (RNAP; α(2)ββ’ωσ(70)), we compare productive and abortive initiation rates, short RNA distributions, and OC lifetime for the λP(R) and T7A1 promoters and variants w...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Henderson, Kate L., Felth, Lindsey C., Molzahn, Cristen M., Shkel, Irina, Wang, Si, Chhabra, Munish, Ruff, Emily F., Bieter, Lauren, Kraft, Joseph E., Record, M. Thomas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393250/
https://ncbi.nlm.nih.gov/pubmed/28348246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618675114
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