Temperature effects on RNA polymerase initiation kinetics reveal which open complex initiates and that bubble collapse is stepwise

Transcription initiation is highly regulated by promoter sequence, transcription factors, and ligands. All known transcription inhibitors, an important class of antibiotics, act in initiation. To understand regulation and inhibition, the biophysical mechanisms of formation and stabilization of the “...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Plaskon, Dylan M., Henderson, Kate L., Felth, Lindsey C., Molzahn, Cristen M., Evensen, Claire, Dyke, Sarah, Shkel, Irina A., Record, M. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325161/
https://ncbi.nlm.nih.gov/pubmed/34290140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021941118
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