WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape

BACKGROUND: Despite PD-L1 (Programmed death receptor ligand-1) expression on tumor cells and cytotoxic T lymphocytes tumor infiltration in the tumor microenvironment, human pancreatic cancer stands out as one of the human cancers that does not respond to immune checkpoint inhibitor (ICI) immunothera...

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Detalles Bibliográficos
Publicado en:J Immunother Cancer
Main Authors: Lu, Chunwan, Liu, Zhuoqi, Klement, John D, Yang, Dafeng, Merting, Alyssa D, Poschel, Dakota, Albers, Thomas, Waller, Jennifer L, Shi, Huidong, Liu, Kebin
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2021
Assuntos:
Clinical/Translational Cancer Immunotherapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323468/
https://ncbi.nlm.nih.gov/pubmed/34326167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002624
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