Autocrine IL6-mediated activation of the STAT3-DNMT axis silences the TNFα-RIP1 necroptosis pathway to sustain survival and accumulation of myeloid-derived suppressor cells

Although accumulation of myeloid-derived suppressor cells (MDSC) is a hallmark of cancer, the underlying mechanism of this accumulation within the tumor microenvironment remains incompletely understood. We report here that TNFα-RIP1-mediated necroptosis regulates accumulation of MDSCs. In tumor-bear...

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Publicat a:Cancer Res
Autors principals: Smith, Alyssa D., Lu, Chunwan, Payne, Daniela, Paschall, Amy V., Klement, John D., Redd, Priscilla S., Ibrahim, Mohammed L., Yang, Dafeng, Han, Qimei, Liu, Zhuoqi, Shi, Huidong, Hartney, Thomas J., Nayak-Kapoor, Asha, Liu, Kebin
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416440/
https://ncbi.nlm.nih.gov/pubmed/32554751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-3670
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